Evaluasi Efek Samping Penggunaan Obat Tetes Mata Kortikosteroid Pada Pasien Pasca Operasi Di Instalasi Farmasi Rumah Sakit Mata Jakarta Eye Center Kedoya

Ihsanil Husna, Diana Laila Ramatillah, Yunita Dian Anggraeni

Abstract


ABSTRAK

Obat golongan kortikosteroid termasuk golongan obat yang sangat penting dalam dunia pengobatan. Salah satu penggunaannya yaitu dalam pemberian topikal pada mata pada pasien pasca operasi. Efek samping yang sering ditemui bila menggunakan obat tetes mata kortikosteroid ialah reaksi alergi sesaat serta dalam jangka waktu yang lama yaitu akanmeningkatkan tekanan intra okluar (TIO) yang bisa menyebabkan glaukoma. Lama penggunaan obat tetes mata kortikosteroid pun berpengaruh terhadap pemberian obat penurun TIO. Penelitian ini bertujuan untuk melihat gambaran efek samping penggunaan obat tetes mata kortikosteroid serta lama penggunaan obat tetes mata kortikosteroid.Data yang diperoleh dari hasil penelitian ini yaitu lama penggunaan  obat tetes mata kortikosteroid pasca operasi yaitu lebih dari 30 hari. Sebanyak 32,31% tidak mengalami efek samping, 23,08% pasien mengalami perih, 13,85% pasien mengeluhkan buram. Pasien yang mengalami efek samping samping merah, pusing, dan ganjal masing-masing sebesar 3,08% dan sebanyak 21,54% pasien mengalami efek samping gabungan. Efek samping berupa peningkatan tekanan intra okuler terjadi pada 33,85% pasien.

 

Kata kunci:kortikosteroid, efek samping, TIO, glaukoma

 

ABSTRACT

Corticosteroid drugs are a class of drugs that are very important in the world of medicine. One of its uses is in topical administration to the eye in postoperative patients. Side effects that are often found when using corticosteroid eye drops are instantaneous allergic reactions and for a long period of time that will increase intra-external pressure (IOP) which can cause glaucoma. The duration of use of corticosteroid eye drops also affects the administration of IOP-lowering drugs. This study aims to look at a picture of the side effects of using corticosteroid eye drops and the duration of use of corticosteroid eye drops. The data obtained from the results of this study are the duration of use of postoperative corticosteroid eye drops which is more than 30 days. A total of 32.31% did not experience side effects, 23.08% of patients experienced pain, 13.85% of patients complained of blurring. Patients who experienced side effects of red, dizzy, and bumpy were 3.08% respectively and 21.54% of patients experienced combined side effects. Side effects in the form of increased intraocular pressure occurred in 33.85% of patients.

Keywords: corticosteroids, side effects, IOP, glaucoma


References


Supadmi W, Aristia BF. Evaluasi Penggunaan Kortikosteroid Pada Pasien Anak di RSU PKU Muhammadiyah Yogyakarta Januari-Maret 2015. J Ilm Ibnu Sina. 2018;3(1):168–78.

Azis AL. Penggunaan kortikosteroid di klinik (The use of corticosteroid in clinics). FK Unair/RSUD dr.Soetomo; 2013.

Hutauruk JA, Siregar SB. Katarak: 101 Jawaban Atas Pertanyaan Anda. Jakarta: Gramedia; 2017.

Ltd. MP. MIMS Drugs References. 141st ed. Jakarta: PT. Medidata Indonesia; 2018. 376 p.

Kizior R, Hodgson B. Saunders Nursing Drug Handbook. USA: Elsevier Ltd; 2016. 141 p.

Hamilton RJ. Tarascon Pharmacopoeia. Philadelphia: Drexel University of Medicine; 2014. 380–381 p.

Jain D, Dangda S, Yadava U, Gupta S. Historical Review of Steroid-Induced Glaucoma. Curr J Glaucoma Pract with DVD. 2010;4(September 2010):109–13.

Mayangsari E, Lestari B, Soeharto S, Nurdiana, Permatasari N, Kalsum U, et al. Farmakologi Dasar. Malang: UB Press; 2017. 139–140 p.

Artini W. Steroid-Induced Glaucoma. FKUI; 2012.

Dhaou BB Ben, Boussema F, Aydi Z, Baili L, Tira H, Rokbani L. Corticoid-Associated Complications in Elderly. Tunis Med. 2012;90(11):774–7.

Dada T, Nair S, Dhawan M, Bhartiya S. Steroid Induced Glaucoma. Kerala J Ophthalmol [Internet]. 2009;XXI(4):345–50. Available from: http://www.ncbi.nlm.nih.gov/pubmed/28613653

Phulke S, Kaushik S, Kaur S, Pandav SS. Steroid-induced Glaucoma: An avoidable irreversible blindness. J Curr Glaucoma Pract. 2017;11(2):67–72.

Chang DTW, Herceg MC, Bilonick RA, Camejo L, Schuman JS, Noecker RJ. Intracameral dexamethasone reduces inflammation on the first postoperative day after cataract surgery in eyes with and without glaucoma. Clin Ophthalmol. 2009;3(1):345–55.


Refbacks

  • There are currently no refbacks.