Ahmad Irfandi



Dengue hemorrhagic fever is still a problem of infectious disease not only in Indonesia but also in the world and even have increased 30-fold over the last 50 years. It is necessary for appropriate control methods to overcome the problem of this disease. This study aims to analyze the impact of Wolbachia against the mosquito Aedes aegypti, dengue virus, and ecology. This study uses a systematic review of the design. Data sourced at 5 journal databases and reports on the development research activities Eliminate Dengue Project in Yogyakarta discovered 22 research journals that match the criteria of inclusion. The study found the impact of Wolbachia in Aedes aegypti mosquitoes resulted in changes the character. Against dengue virus, Wolbachia is able to block the virus so that the virus retained in the body of the mosquito. While on the ecosystem of Wolbachia causes cytoplasmic incompatibility so that Aedes aegypti infected can only produce offspring with the same strain of Wolbachia and ecosystem change. The conclusion from this study that Wolbachiahave positive impact to reduction virus in the mosquitoe’s body, but to continue the spread of Wolbachia in other locations should examine the impact of ecosystem changes in the site that has done spread of Wolbachia.


Keywords:wolbachia, systematic review, dhf, ecosystem



Demam berdarah dengue masih menjadi masalah penyakit menular hingga saat ini di Indonesia maupun dunia bahkan telah meningkat 30 kali lipat selama 50 tahun terakhir. Untuk itu diperlukan metode pengendalian yang tepat untuk mengatasi masalah penyakit ini. Penelitian ini bertujuan untuk menganalisis dampakWolbachia terhadap nyamuk Aedes aegypti, virus Dengue, dan ekosistem dengan menggunakan studi literatur dan studi kasus pemanfaatan Wolbachia di Yogyakarta. Penelitian ini menggunakan desain systematic review. Data bersumber pada 5 database jurnal dan laporan perkembangan kegiatan penelitian Eliminate Dengue Project Yogyakarta ditemukan 22 jurnal penelitian yang sesuai kriteria inklusi. Studi ini menemukan dampak Wolbachia pada nyamuk Aedes aegypti mengakibatkan perubahan sifat pada nyamuk. Terhadap virus dengue, Wolbachia mampu memblok virus sehingga virus tertahan di tubuh nyamuk. Sedangkan terhadap ekosistem Wolbachia menyebabkan ketidakcocokan sitoplasma sehingga nyamuk Aedes aegypti ber-Wolbachia hanya mampu menghasilkan keturunan dengan strain Wolbachia yang sama dan terjadinya perubahan ekosistem. Kesimpulan dari penelitian ini bahwa Wolbachia berdampak positif terhadap penurunan jumlah virus dalam tubuh nyamuk namun untuk melanjutkan penyebaran Wolbachia di lokasi lain sebaiknya diteliti dampak perubahan ekosistem dari lokasi yang telah dilakukannya penyebaranWolbachia.


Kata kunci:wolbachia, systematic review, dbd, ekosistem.

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